Third part on logistic regression (first here, second here).

Two steps in assessing the fit of the model: first is to determine if the model fits using summary measures of goodness of fit or by assessing the predictive ability of the model; second is to deterime if there’s any observations that do not fit the model or that have an influence on the model.

**Covariate pattern**

A covariate pattern is a unique combination of values of predictor variables.

mod3 <- glm(casecont ~ dcpct + dneo + dclox + dneo*dclox, + family = binomial("logit"), data = nocardia) summary(mod3) Call: glm(formula = casecont ~ dcpct + dneo + dclox + dneo * dclox, family = binomial("logit"), data = nocardia) Deviance Residuals: Min 1Q Median 3Q Max -1.9191 -0.7682 0.1874 0.5876 2.6755 Coefficients: Estimate Std. Error z value Pr(>|z|) (Intercept) -3.776896 0.993251 -3.803 0.000143 *** dcpct 0.022618 0.007723 2.928 0.003406 ** dneoYes 3.184002 0.837199 3.803 0.000143 *** dcloxYes 0.445705 1.026026 0.434 0.663999 dneoYes:dcloxYes -2.551997 1.205075 -2.118 0.034200 * --- Signif. codes: 0 ‘***’ 0.001 ‘**’ 0.01 ‘*’ 0.05 ‘.’ 0.1 ‘ ’ 1 (Dispersion parameter for binomial family taken to be 1) Null deviance: 149.72 on 107 degrees of freedom Residual deviance: 103.42 on 103 degrees of freedom AIC: 113.42 Number of Fisher Scoring iterations: 5 library(epiR) Package epiR 0.9-45 is loaded Type help(epi.about) for summary information mod3.mf <- model.frame(mod3) (mod3.cp <- epi.cp(mod3.mf[-1])) $cov.pattern id n dcpct dneo dclox 1 1 7 0 No No 2 2 38 100 Yes No 3 3 1 25 No No 4 4 1 1 No No 5 5 11 100 No Yes 8 6 1 25 Yes Yes 10 7 1 14 Yes No 12 8 4 75 Yes No 13 9 1 90 Yes Yes 14 10 1 30 No No 15 11 3 5 Yes No 17 12 9 100 Yes Yes 22 13 2 20 Yes No 23 14 8 100 No No 25 15 2 50 Yes Yes 26 16 1 7 No No 27 17 4 50 Yes No 28 18 1 50 No No 31 19 1 30 Yes No 34 20 1 99 No No 35 21 1 99 Yes Yes 40 22 1 80 Yes Yes 48 23 1 3 Yes No 59 24 1 1 Yes No 77 25 1 10 No No 84 26 1 83 No Yes 85 27 1 95 Yes No 88 28 1 99 Yes No 89 29 1 25 Yes No 105 30 1 40 Yes No $id [1] 1 2 3 4 5 1 1 6 5 7 5 8 9 10 11 11 12 1 12 1 5 13 14 2 15 [26] 16 17 18 1 2 19 2 14 20 21 12 14 5 8 22 14 5 5 5 1 14 14 23 2 12 [51] 14 12 11 5 15 2 8 2 24 2 2 8 2 17 2 2 2 2 12 12 12 2 2 2 5 [76] 2 25 2 17 2 2 2 2 26 27 13 17 28 29 14 2 12 2 2 2 2 2 2 2 2 [101] 2 2 2 2 30 2 2 5

There are 30 covariate patterns in the dataset. The pattern dcpct=100, dneo=Yes, dclox=No appears 38 times.

**Pearson and deviance residuals**

Residuals represent the difference between the data and the model. The Pearson residuals are comparable to standardized residuals used for linear regression models. Deviance residuals represent the contribution of each observation to the overall deviance.

residuals(mod3) # deviance residuals residuals(mod3, "pearson") # pearson residuals

**Goodness-of-fit test**

All goodness-of-fit tests are based on the premise that the data will be divided into subsets and within each subset the predicted number of outcomes will be computed and compared to the observed number of outcomes. The Pearson and the deviance are based on dividing the data up into the natural covariate patterns. The Hosmer-Lemeshow test is based on a more arbitrary division of the data.

The Pearson is similar to the residual sum of squares used in linear models. It will be close in size to the deviance, but the model is fit to minimize the deviance and not the Pearson . It is thus possible even if unlikely that the could increase as a predictor is added to the model.

sum(residuals(mod3, type = "pearson")^2) [1] 123.9656 deviance(mod3) [1] 103.4168 1 - pchisq(deviance(mod3), df.residual(mod3)) [1] 0.4699251

The p-value is large indicating no evidence of lack of fit. However, when using the deviance statistic to assess the goodness-of-fit for a nonsaturated logistic model, the approximation for the likelihood ratio test is questionable. When the covariate pattern is almost as large as N, the deviance cannot be assumed to have a distribution.

Now the Hosmer-Lemeshow test, usually dividing by 10 the data:

hosmerlem <- function (y, yhat, g = 10) { + cutyhat <- cut(yhat, breaks = quantile(yhat, probs = seq(0, 1, 1/g)), + include.lowest = TRUE) + obs <- xtabs(cbind(1 - y, y) ~ cutyhat) + expect <- xtabs(cbind(1 - yhat, yhat) ~ cutyhat) + chisq <- sum((obs - expect)^2 / expect) + P <- 1 - pchisq(chisq, g - 2) + c("X^2" = chisq, Df = g - 2, "P(>Chi)" = P) + } hosmerlem(y = nocardia$casecont, yhat = fitted(mod3)) Erreur dans cut.default(yhat, breaks = quantile(yhat, probs = seq(0, 1, 1/g)), (depuis #2) : 'breaks' are not unique

The model used has many ties in its predicted probabilities (too few covariate values?) resulting in an error when running the Hosmer-Lemeshow test. Using fewer cut-points (g = 5 or 7) does not solve the problem. This is a typical example when not to use this test. A better goodness-of-fit test than Hosmer-Lemeshow and Pearson / deviance tests is the le Cessie – van Houwelingen – Copas – Hosmer unweighted sum of squares test for global goodness of fit (also here) implemented in the rms package (but you have to implement your model with the lrm function of this package):

mod3b <- lrm(casecont ~ dcpct + dneo + dclox + dneo*dclox, nocardia, + method = "lrm.fit", model = TRUE, x = TRUE, y = TRUE, + linear.predictors = TRUE, se.fit = FALSE) residuals(mod3b, type = "gof") Sum of squared errors Expected value|H0 SD 16.4288056 16.8235055 0.2775694 Z P -1.4219860 0.1550303

The p-value is 0.16 so there’s no evidence the model is incorrect. Even better than these tests would be to check for linearity of the predictors.

**Overdispersion**

Sometimes we can get a deviance that is much larger than expected if the model was correct. It can be due to the presence of outliers, sparse data or clustering of data. The approach to deal with overdispersion is to add a dispersion parameter . It can be estimated with: (p = probability of success). A half-normal plot of the residuals can help checking for outliers:

library(faraway) halfnorm(residuals(mod1))

The dispesion parameter of model 1 can be found as:

(sigma2 <- sum(residuals(mod1, type = "pearson")^2) / 104) [1] 1.128778 drop1(mod1, scale = sigma2, test = "F") Single term deletions Model: casecont ~ dcpct + dneo + dclox scale: 1.128778 Df Deviance AIC F value Pr(>F) <none> 107.99 115.99 dcpct 1 119.34 124.05 10.9350 0.001296 ** dneo 1 125.86 129.82 17.2166 6.834e-05 *** dclox 1 114.73 119.96 6.4931 0.012291 * --- Signif. codes: 0 ‘***’ 0.001 ‘**’ 0.01 ‘*’ 0.05 ‘.’ 0.1 ‘ ’ 1 Message d'avis : In drop1.glm(mod1, scale = sigma2, test = "F") : le test F implique une famille 'quasibinomial'

The dispersion parameter is not very different than one (no dispersion). If dispersion was present, you could use it in the F-tests for the predictors, adding scale to drop1.

**Predictive ability of the model**

A ROC curve can be drawn:

predicted <- predict(mod3) library(ROCR) prob <- prediction(predicted, nocardia$casecont, + label.ordering = c('Control', 'Case')) tprfpr <- performance(prob, "tpr", "fpr") tpr <- unlist(slot(tprfpr, "y.values")) fpr <- unlist(slot(tprfpr, "x.values")) roc <- data.frame(tpr, fpr) ggplot(roc) + geom_line(aes(x = fpr, y = tpr)) + + geom_abline(intercept = 0, slope = 1, colour = "gray") + + ylab("Sensitivity") + + xlab("1 - Specificity")

**Identifying important observations**

Like for linear regression, large positive or negative standardized residuals allow to identify points which are not well fit by the model. A plot of Pearson residuals as a function of the logit for model 1 is drawn here, with bubbles relative to size of the covariate pattern. The plot should be an horizontal band with observations between -3 and +3. Covariate patterns 25 and 26 are problematic.

nocardia$casecont.num <- as.numeric(nocardia$casecont) - 1 mod1 <- glm(casecont.num ~ dcpct + dneo + dclox, family = binomial("logit"), + data = nocardia) # "logit" can be omitted as it is the default mod1.mf <- model.frame(mod1) mod1.cp <- epi.cp(mod1.mf[-1]) nocardia.cp <- as.data.frame(cbind(cpid = mod1.cp$id, + nocardia[ , c(1, 9:11, 13)], + fit = fitted(mod1))) ### Residuals and delta betas based on covariate pattern: mod1.obs <- as.vector(by(as.numeric(nocardia.cp$casecont.num), + as.factor(nocardia.cp$cpid), FUN = sum)) mod1.fit <- as.vector(by(nocardia.cp$fit, as.factor(nocardia.cp$cpid), + FUN = min)) mod1.res <- epi.cpresids(obs = mod1.obs, fit = mod1.fit, + covpattern = mod1.cp) mod1.lodds <- as.vector(by(predict(mod1), as.factor(nocardia.cp$cpid), + FUN = min)) plot(mod1.lodds, mod1.res$spearson, + type = "n", ylab = "Pearson Residuals", xlab = "Logit") text(mod1.lodds, mod1.res$spearson, labels = mod1.res$cpid, cex = 0.8) symbols(mod1.lodds, mod1.res$pearson, circles = mod1.res$n, add = TRUE)

The hat matrix is used to calculate leverage values and other diagnostic parameters. Leverage measures the potential impact of an observation. Points with high leverage have a potential impact. Covariate patterns 2, 14, 12 and 5 have the largest leverage values.

mod1.res[sort.list(mod1.res$leverage, decreasing = TRUE), ] cpid leverage 2 0.74708052 14 0.54693851 12 0.54017700 5 0.42682684 11 0.21749664 1 0.19129427 ...

Delta-betas provides an overall estimate of the effect of the covariate pattern on the regression coefficients. It is analogous to Cook’s distance in linear regression. Covariate pattern 2 has the largest delta-beta (and represents 38 observations).

mod1.res[sort.list(mod1.res$sdeltabeta, decreasing = TRUE), ] cpid sdeltabeta 2 7.890878470 14 3.983840529 ...